Bacterial infections in relation to medical implants place a heavy burden on health care and cause great distress to patients worldwide. Now, researchers from Chalmers College of Expertise, Sweden, have developed a new technique to prevent such infections, by protecting a graphene-based material with bactericidal molecules.
“Through our analysis, we have been able to bind water-insoluble antibacterial molecules to graphene, and launch the molecules from the fabric in a managed, stable method”, says Santosh Pandit, researcher in the Department of Biology and Organic Engineering. Chalmers, and the first producers of research that recently appeared in Scientific Reports.
“This is an important requirement for the strategy to work. The best way in which we bind energetic molecules to graphene may be quite simple, and could possibly only be made in industrial processes”.
Certainly microbes can form impermeable floor layers, or ‘biofilms’, on surgical implants, reminiscent of dental and various orthopedic implants, and indicate a serious shortage of healthcare globally.
Biofilms are more resistant than other microorganisms, and infections occur due to the fact that they are usually difficult to treat, resulting in great struggle for patients, and in the worst cases, removal of the implant or the need for alternatives. is required. With consequences on patients, this requires large costs for healthcare providers.
Graphene is suitable as an attachment material
There are many water-insoluble, or hydrophobic, drugs and molecules that can be used for their antibacterial properties. However, to ensure that they are used in the body, they must be attached to a fabric, which can be difficult and laborious to make.
“Graphene offers great potential right here for interaction with hydrophobic molecules or drug, and once we created our new material, we harnessed those properties. The method of binding antibacterial molecules is with the aid of ultrasound, Says Santosh Pandit.
Within the research, graphene materials were coated with unic acid, which is extracted from lichens, for example fruticose lichens. Earlier analysis has proved that usnic acid has good bactericidal properties. It actually inhibits micro-organisms from making nucleic acids, specifically inhibiting RNA synthesis, and thus preventing protein formation within the cell.
Easy technology paves the way for medicine of the future
Usnic acid was investigated for resistance to the pathogenic micro-organisms Staphylococcus aureus and Staphylococcus epidermidis, two widespread culprits for biofilm formation on medical implants. The researchers’ new materials displayed quite promising properties.
With beneficial results for integrating unic acid into the floor of graphene materials, they also observed that the unic acid molecules were launched in a managed and stable manner, thus preventing the formation of biofilms on the floor.
“More importantly, our results show that the strategy for binding hydrophobic molecules to graphene is simple. This sooner or later paves the best path for simple antibacterial protection of biomedical merchandise. We plan to actually test this.” where we are going to discover different hydrophobic molecules and drugs that have greater potential to combat or prevent various medical infections,” says Santosh Pandit.